Part No: Issued year: 2015File size: 0.94mbFile type: pdf
The crossreactivity of molecularly imprinted polymers (MIPs) and its
practical implications are discussed. Screening of MIP libraries is presented as a
fasttrack route to discovery of resins selective towards new targets, exploiting the
fact that MIPs imprinted with one type of template molecule also show recognition
to related and sometimes also to apparently unrelated molecules. Several examples
from our own and others’ studies are presented that illustrate this crossreactivity and
the pattern of recognition is discussed for selected examples.
Part No: PPS468Issued year: 2017File size: 0.71mbFile type: pdf
Producing peptides for research is challenging. Biotage has developed
a holistic approach to the entire peptide workflow via an automated solution, designed for dedicated peptide researchers and those new to the field.
Part No: PPS463Issued year: 2017File size: 1.74mbFile type: pdf
Traditional approaches to compound purification involving chromatography utilize large volumes of relatively toxic and expensive solvents, and significantly contribute to the environmental footprint of organizations involved in molecular research. Current directives for greener chemistry have put pressure on organizations to reduce the
environmental impact of their work.
Part No: PPS466Issued year: 2017File size: 1.4mbFile type: pdf
Using the Biotage automated workflow, models have shown that the time taken to produce a target molecule can be reduced by up to eighty percent, allowing project delivery timescales to be reduced
Part No: PPS356Issued year: 2014File size: 1.19mbFile type: pdf
To save money on consumables, many chemists choose to reuse
silica flash cartridges. This is true but risks purification results because chromatographic separation performance will change from run to run which reduces purification quality, especially in normal phase systems.
Regardless of the cartridge brand used, repeated use of silica flash cartridges results in loss of compound resolution and therefore fraction purity.
Part No: TN121Issued year: 2006File size: 0.07mbFile type: pdf
In medicinal chemistry reactions are often carried out in solvents such as DMSO. Once the reaction is complete, it is usually necessary to separate the products of the reaction from reagents and by-products. This can be performed using strong cation exchange sorbents (e.g. ISOLUTE SCX-2 or ISOLUTE Flash SCX-2) to selectively isolate the basic compounds from the reaction mixture. (see Figure 1 for structure of ISOLUTE SCX-2 and ISOLUTE Flash SCX-2 sorbents)
Part No: TN135.06Issued year: 2006File size: 0.09mbFile type: pdf
One of the most common work-up techniques in medicinal chemistry is liquid-liquid extraction (LLE) using a
separating funnel. The technique is used for removal of water soluble impurities, solvent exchange, water
removal or work-up of aqueous reaction mixtures.
Part No: TN135Issued year: 2006File size: 0.1mbFile type: pdf
One of the most common work-up techniques in medicinal chemistry is liquid-liquid extraction (LLE). The technique is used for removal of water soluble impurities, solvent exchange, water removal or work-up of aqueous reaction mixtures.
Part No: PPS352.v3Issued year: 2015File size: 7.34mbFile type: pdf
Biotage offers a range of products for reaction mixture work-up and organic sample preparation. The solutions include a range of techniques and also address throughput requirements from filtration, catch & release, and scavenging cartridges in organic synthesis workflows.