This poster evaluates the performance of a novel 96-well filter plate (ISOLUTE PLD+ Protein and Phospholipid Removal Plate) for the simultaneous removal of proteins and phospholipids from serum samples prior to LC-MS/MS analysis. ASMS2014

96-well plate Acidic Amitriptyline Analgesics Atenolol Basic Bretylium Clinical English Fluoxetine Forensic Ketoprofen LC-MS/MS Metoprolol Mianserin NSAIDs Naltrexone Pharma Plasma Posters Procainamide Quinidine Ranitidine Salbutamol Serum Sulindac Tricyclic Antidepressant β-blockers

This poster presents the ISOLUTE PLD+ Protein and Phospholipid removal plate, highlighting its ease of use and excellent performance with respect to sample clean up, analyte recovery and elimination of back pressure build up in the UPLC system. IMSC 2014

96-well plate Acetaminophen Acidic Amitriptyline Atenolol Basic Bretylium Brompheniramine Clinical English Fluoxetine Forensic Ketoprofen LC-MS/MS Metoprolol Mianserin Naltrexone Neutral Pharma Pharmaceuticals Plasma Posters Procainamide Quinidine Ranitidine Salbutamol Sulindac p-toluamide

EVOLUTE® EXPRESS SPE columns and plates combine sorbent wettability with optimized SPE components, allowing better flow consistency and in many cases eliminating the need for SPE column conditioning; thus simplifying and reducing extraction processing. This poster compares the performance of various EVOLUTE EXPRESS column chemistries using 10-500 mg bed weights, in order to investigate whether sorbent conditioning and equilibration steps are truly required. ASMS 2015

Acidic Amitriptyline Atenolol Benzenesulfonic acid Bretylium Clinical Column Diethyldithiophosphate (DEDTP) Dimethylthiophosphate (DMTP) English Extrahera Forensic Hexanesulfonic acid Ketoprofen LC-MS/MS Metoprolol Mianserin Organophosphate Pesticide Over the counter pharmaceuticals Pain Management Pharma Pharmaceuticals Posters Prednisolone Procainamide Quaternary Amines Quinidine Salbutamol Sulindac Tricyclic Antidepressant Urine β-blockers

This application note describes the use of the ISOLUTE® PLD+ Protein and Phospholipid Removal Plate for clean-up of a range of acidic, basic and neutral drugs from plasma. ISOLUTE® PLD+ Protein and Phospholipid Removal Plates are suitable for clean-up of a range of analytes with widely differing functionality and polarity characteristics from plasma, giving high recoveries, good reproducibility and excellent extract cleanliness.

96-well plate Acetaminophen Acidic Amitriptyline Application Notes Atenolol Basic Bretylium Brompheniramine Clinical English Fluoxetine Forensic Ketoprofen LC-MS/MS Metoprolol Mianserin NSAIDs Naltrexone Neutral Pharma Plasma Procainamide Quinidine Ranitidine Salbutamol Sulindac Tricyclic Antidepressant p-toluamide β-blockers

This Application Note describes the extraction of a variety of basic drugs from plasma using EVOLUTE® CX mixed-mode resin-based SPE. The analyte suite includes basic drugs with wide ranging pKa and logP values. Basic Drugs, Biotage, Ion Exchange, EVOLUTE, Pharmaceuticals

Amitriptyline Application Notes Atenolol Basic Clinical Fluoxetine LC-MS/MS Metoprolol Mianserin Naltrexone Plasma Procainamide Quinidine Ranitidine Salbutamol