Mitsunobu reaction scheme.
Wittig reaction scheme.
Biotage® PS-Triphenylphosphine is a diphenylphosphinated polystyrene resin that is a solid-supported equivalent of triphenylphosphine. The resin can readily convert alcohols or carboxylic acids to the corresponding chlorides or acid chlorides in carbon tetrachloride. PS-Triphenylphosphine can also be used in Mitsunobu reactions to prepare aryl ethers in good-to-excellent yields and in high purities. The procedures provide pure products without the need for laborious silica gel chromatography.
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