As the popularity of post-synthetic peptide chemistry continues to go, additional purification strategies will be required. Standard reversed phase techniques may be ineffecient due to the extreme hydrophobicity imbued by the presence of sidechain protecting groups. Herein, we demonstrate that normal phase chromatography, specifically the use of a methanol:DCM solvent system and a step gradient, can indeed facilitate rapid purification of fully protected peptides.
Achieve Highly Pure Peptides Using High Performance Flash Chromatography
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New UV Monitor Kit for Large Scale Purification
Peptide Workflow by Biotage
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