Biotage® PS-HOBt(HL) is a sulfonamide-linked, polymer supported equivalent of 1-hydroxybenzotriazole (HOBt) and is used to generate bound HOBt active esters. Treatment of bound HOBt esters with an amine leads to amide formation in generally high purity without the need for further purification and the supported reagent may also be used catalytically.
We describe an efficient loading procedure based on the use of diisopropylcarbodiimide and DMAP.
The procedure has proven to be much more reliable and building-block cost effective for this resin.
Read more about the versatility of this supported reagent in the document below.