Starting out with p-hydroxybenzaldehyde, a four step synthetic pathway led to the synthesis of a benzofuran derivative in high yield and purity using Biotage® Endeavor™ catalyst screening system. With eight parallel reaction chambers, one single run was sufficient to identify optimal catalyst and reaction conditions. The system also handled the final catalytic alkene hydrogenation step while monitoring pressure and temperatures.
Scheme 1. Synthesis of Benzofuranylmethyl-2,4-Thiazolidinediones.
Biotage Industrial Flash Cartridges Explained
Finally - an Easy Urine Sample Preparation for LC/MS Analysis
A Smorgasbord of Analytical Methods
Extraction of Acidic Catecholamine Metabolites in Plasma Using EVOLUTE® EXPRESS ABN Prior to LC-MS/MS Analysis
Seminar: An Introduction to the Biotage Automated Workflow Solution