Starting out with p-hydroxybenzaldehyde, a four step synthetic pathway led to the synthesis of a benzofuran derivative in high yield and purity using Biotage® Endeavor™ catalyst screening system. With eight parallel reaction chambers, one single run was sufficient to identify optimal catalyst and reaction conditions. The system also handled the final catalytic alkene hydrogenation step while monitoring pressure and temperatures.
Scheme 1. Synthesis of Benzofuranylmethyl-2,4-Thiazolidinediones.
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