As medicinal chemistry broadens its scope beyond Lipinski’s rule of 5, compounds with more polar functionality and complexity are being created. Often, these compounds are too polar/ionizable for normal phase purification and therefore require reversed phase chromatography.
Though conventional 50 μm C18 media will often suffice, the increased molecular complexity usually needs more resolution to enable quality purification. This poster shows how the new high-performance reversed phase flash cartridge Biotage® SNAP Ultra C18 increases separation power and increases loading capacity 2x over conventional C18 cartridges.
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