Despite the widespread use of palladium-mediated catalytic reactions, handling and removal of palladium during reactions and work-up present challenges that continues to remain a major problem. Reducing palladium content to parts per million level, as is required for active pharmaceutical ingredients, is particularly challenging and addressable via metal scavengers, but effective introduction of stable workhorse palladium catalysts to reactions can be challenging.
The Suzuki reaction is one of the most widely practiced coupling protocols for the preparation of symmetrical and unsymmetrical biaryl compounds. Biotage® PS-PPh3-Pd was developed to perform in a manner similar to that of the well-established small molecule reagent Pd(Ph3P)4, with the additional convenience of a polymer supported reagent for handling and purification. PS-PPh3-Pd is stable to air and can be stored at room temperature for extended periods of time without degradation. A reaction protocol using PS-PPh3-Pd typically results in excellent yield and purity, with <100 ppm residual palladium.