For many chemists performing bench-scale organic synthesis, flash column chromatography is the primary purification technique. When your synthesis needs scaling to multi-gram levels, so does the flash purification. In its basic form, scaling flash purification is a simple numbers game of maintaining ratios. The logical approach is to just increase the flash cartridge or column size, but this is only part of the solution.
Scaling-up flash chromatography separations can seem a daunting task if you haven’t done it before, but in fact it is a fairly straightforward process once you determine the following:
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