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Scaling Up Flash Purification – Easy as 1, 2, 3, 4

13 November 2015

This blog post on the Flash Purification Blog discusses the process of simplified flash purification scale-up.

 

For many chemists performing bench-scale organic synthesis, flash column chromatography is the primary purification technique. When your synthesis needs scaling to multi-gram levels, so does the flash purification. In its basic form, scaling flash purification is a simple numbers game of maintaining ratios. The logical approach is to just increase the flash cartridge or column size, but this is only part of the solution.

Scaling-up flash chromatography separations can seem a daunting task if you haven’t done it before, but in fact it is a fairly straightforward process once you determine the following:

  1. What cartridge size is appropriate for my reaction scale?
  2. What load amount and loading technique should I use?
  3. What gradient should be run?
  4. What flow rate should I use with the larger cartridge?

Read the full blog post here »