This application note describes the synthesis of a branched peptidoglycan mimic and the synthesis of a tetra-branched antimicrobial peptide analogue (MAP) on a lysine scaffold using Biotage® Initiator+ Alstra™ microwave peptide synthesizer. These peptide modifications are challenging to synthesize and automate, however, the procedure was operationally simplified using Branches™.
The research for this application note was carried out in the group of Prof. Knud J. Jensen at the University of Copenhagen.
Branched peptidoglycan mimic (left) and Tetra-branched antimicrobial peptide analogue (MAP).
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