Cyclosporine is an immunosuppressant used in organ transplants to overcome rejection. Following the transplant of a heart, liver, kidney or lung, a patient must be regularly tested for the rest of their lives. Blood testing intervals vary from 1 month to 6 months and this rapid reference method is ideal for batch tests with the advantage of no metabolite interfer-ence which is always found in immunological methods.
Tags: Application Notes, Liver

The removal of interferences and sample concentration are essential steps in trace level detection of pesticides, sheep dips, herbicides and PCBs in river water, wastewaters and trade effluents. The following methods were developed by the Environment Agency National Laboratory Service facility at Nottingham using the Biotage RapidTrace for automated solid phase extraction and the TurboVap II for evaporation. The procedures are UKAS accredited and can reach detection limits of 0.001 ug/Litre for some compounds.
Tags: Application Notes, Environmental, Environmental contaminants, Organophosphates, RapidTrace, Water

With the widespread clinical use of antidepressant drugs comes the need to accurately measure therapeutic lev-els to determine proper dosage, as well as check for toxic levels and patient compliance. More and more laboratories are shifting their therapeutic drug monitor-ing from liquid extraction to solid phase extraction. A large clinical laboratory has automated the process of extracting these drugs from serum using the RapidTrace SPE Workstation.
Tags: Application Notes

EPA methods 8260 & 8270 cover the analysis of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in ground & surface waters. This also now includes 1,4-dioxane and PCBs. This application note will focus on the automated SPE of the sample rather than the detection which usually involves GCMS or LCMS. NB The columns and reagents used for soils and sediment analysis differ to ground water extraction.
Tags: Application Notes, Environmental, Environmental contaminants, RapidTrace, Soil

The use of schedule I drugs for patient pain management therapy warrants constant monitoring of therapeutic levels in the patient. Screening patient urine samples for the free drugs is complicated by the metabolism process which converts the free drug to the -glucuronide form. Patient urine samples can be enzymatically hydrolyzed to cleave glucuronide moiety and produce the free form of drug. The target analytes can them be extracted from the urine matrix using EVOLUTE CX solid phase extraction cartridges. LOQs range from 5 ng/mL to 0.5 ng/mL with recoveries above 80% and RSD <10% Pain Management, EVOLUTE, CX, SPE, Solid Phase Extraction, Polymer, LC-MS-MS, Cocaine, Diazepam, Heroin, Morphine, Oxycodone, Fentanyl, Diazepam, Mixed Mode, RapidTrace
Tags: Alprazolam, Application Notes, Buprenorphine, Butylone, Clinical, Clonazepam, Codeine, Column, Fentanyl, Flunitrazepam, Hydrocodone, Hydromorphone, LC-MS/MS, Meperidine, Methadone, Morphine, Naloxone, Naltrexone, Oxycodone, Oxymorphone, RapidTrace, Temazepam, Urine

Melamine is traditionally used in making plastics, however, it’s low cost and high nitrogen content has led to exploitation in various sections of the food industry, most notably involving dairy products. Sustained melamine exposure can result in kidney stones and renal failure, with the young being most susceptible. This application note has been optimized on the RapidTrace+; an updated version of the current RapidTrace software which allows the system to process smaller bed heights than were previously possible. The application note shows recoveries of 88-90% with RSDs <10%. Melamine, food scare, china, EVOLUTE, cation exchange, RapidTrace, Automation, SPE, sample prep,
Tags: Application Notes, Column, Food, Food contaminant, LC-MS/MS, Melamine, Milk, RapidTrace

Ethyl glucuronide (EtG, Figure 1.) is an ethanol metabolite formed by the glucuronidation of the parent molecule. The presence of EtG in urine and plasma is a useful and sensitive biomarker of alcohol intake in forensic toxicology. EtG can be detected at very low levels and is useful in distinguishing between ingested ethanol and that which is adsorbed through the skin from ethanol. This application note has been optimized on the RapidTrace+; an updated version of the current RapidTrace software which allows the system to process smaller bed heights than were previously possible. The application note shows analyte recoveries all above 97% with RSDs >10%. EVOLUTE, Resin, EtG, Alcohol, Alcohol Biomarker, metabolite, anion exchange, Strata X, Oasis, Waters,
Tags: Alcohol metabolite, Application Notes, Column, Ethyl glucuronide (EtG), LC-MS/MS, RapidTrace, Urine

This application note describes an automated extraction procedure for the opiates, morphine and codeine from urine using ISOLUTE HCX and the RapidTrace Workstation. Opiates, drug testing, DOA, Ion exchange
Tags: Application Notes, Codeine, Column, Forensic, Morphine, Opiates, RapidTrace, Urine

Cyclosporine (Figure 1) is an immunosuppressant drug most significantly used in post-operative organ transplants to reduce the chance of rejection of donor organs by decreasing the activity of the patient’s immune system. Subsequent to an organ transplant, patients are tested at regular intervals for the presence of very low levels of the compound. Cyclosporine is a cyclic non-ribosomal peptide of 11 amino acids and contains a single D-amino acid. Cyclosporine, Cyclosporine, Immunosuppressant,
Tags: Application Notes, Clinical, Column, Cyclosporin, Cyclosporine, Immunosuppressant, RapidTrace, Whole blood

The typical range of drugs screened using this generic method are Cocaine, D3-Cocaine, Benzoylegonine-TMS, D3-Benzoylegonine-TMS, Amphetamine, D5-Amphetamine, Methamphetamine, Codeine, Morphine, Amitriptyline HCL, Nortriptyline HCL, Imipramine HCL, Desipramine HCL. These drugs represent a panel of the most significantly abused drugs as recommended by The National Institute on Drug Abuse (NIDA). drugs of abuse, drugs testing, amphetamines, BZE, Cocaine, Codeine, Ion exchange,
Tags: Amitriptyline, Amphetamine, Application Notes, Benzoylecgonine, Biological fluids, Butylone, Codeine, Column, Desipramine, Forensic, Imipramine, Methamphetamine, Morphine, Nortryptiline, Plasma, RapidTrace, Tricyclic Antidepressant, Urine

This application note describes an automated extraction procedure from Tricyclic Antidepressants from Whole Blood Using ISOLUTE HCX Columns and the RapidTrace Workstation. TCAD, TCA, Tricyclic antidepressants, ISOLUTE,
Tags: Amitriptyline, Application Notes, Clinical, Column, Desipramine, Imipramine, Nortryptiline, RapidTrace, Tricyclic Antidepressant, Whole blood

This application note describes an automated extraction procedure for Cocaine metabolite, Benzoylecgonine from urine using ISOLUTE HCX and RapidTrace Workstation.
Tags: Application Notes, Benzoylecgonine, Cocaines, Column, Forensic, RapidTrace, Urine

This Application Note describes the operating conditions for the automated fractionation of EPH into aliphatic and PAH fractions using the ISOLUTE EPH column in conjunction with the RapidTrace SPE automation system. EPH, Massachusetts Department of Environmental Protection,
Tags: Aliphatic hydrocarbos, Application Notes, Column, Environmental, Environmental contaminants, Polyaromatic hydrocarbons, RapidTrace, Soil

When analyzing human urine for drugs of abuse, one of the most common tests is for the cocaine metabolite Benzoylecgonine (BZE). A contract laboratory has automated this labor intensive procedure using the RapidTrace.
Tags: Application Notes, Benzoylecgonine, Column, Drugs of Abuse, Forensic, GC-MS, RapidTrace, Urine

The extraction and segregation of Organic compounds from core samples taken from marine sediments is used to predict climate conditions, reconstruct sea temperatures and identify the type of vegetation from the C3 ( Temperate cli-mate) and C4 ( Tropical Climate) isotopic mass spectroscopy ratio analysis.
Tags: Application Notes

This method details extraction of the NIDA-5 (SAMHSA-) drug of abuse classes using the same SPE column (ISOLUTE HCX 130 mg/1 mL) and single set of reagents (8 in total) on the RapidTrace.
Tags: Application Notes, RapidTrace

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Tags: Application Notes, Cocaines, Column, Forensic, RapidTrace

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The following method addresses the extraction of 6-monoacetyl morphine from urine using non-polar and strong cation exchange retention mechanisms. This compound can confirm heroine use since it is a heroine metabolite, but not a metabolite of codeine or morphine
Tags: Application Notes, Codeine, RapidTrace, Urine

The RapidTrace+ is a robust automated platform for quickly developing rugged, reliable SPE methods in regulated pharmaceutical, clinical and forensic laboratories. The RapidTrace+ eliminates SPE bottlenecks so you can realize the full benefits of today’s powerful analytical instruments.
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In this catalog product information is displayed with easy-to-follow application details and supporting documentation. Ordering information is found following each product listing.
Tags: Catalogs

Declaration of Conformtiy RapidTrace
Tags: Certificates, Clinical, English, Environmental, Food, Forensic, Product Notes

User report: RapidTrace. The Laboratory of Racing Chemistry (LRC) analyzes samples from racehorses for doping drug. In order to screen approximately 1000 samples per week, LRC use an array of Biotage RapidTrace automated SPE systems. In an interview, Mr. Kenji Kinoshita and Mr. Kensaku Shirai talked about their experiences with the RapidTrace system in processing the heavy workload.
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Tags: English, Manuals & User Guides, RapidTrace

A GC-MSMS method of simultaneously measuring legacy/emerging POPs PCBs, OCPs and PBDEs) in serum was developed and applied to this study of exposure of mothers to harmful environmental contaminants.
Tags: BHC, Clinical, DDE, DDT, English, Environmental, GC-MS, HCB, Organochlorine pesticides (OCP), Organochlorines, Oxychlordane, PBDE, PBDEs, PCB, PCBs, Persistant organic pollutants (POP), Posters, RapidTrace, Serum, Trans-nonachlor

This poster describes an automated procedure for isolation and clean up of 15 F2t-isoprostane (8-iso Prostaglandin 2a)(a lipid marker of oxidative stress) from BSA.
Tags: 15 F2t-isoprostane, 8-iso Prostaglandin2a, BSA, Biological fluids, Biomarker, Clinical, Column, English, GC-MS, Lipids, Posters, RapidTrace

Declaration of Conformtiy RapidTrace
Tags: Certificates, Clinical, English, Environmental, Food, Forensic, Product Notes

In order to keep your RapidTrace® workstation clean, in good working order and free from contamination it is of course essential to routinely clean and purge the fluid path. Whichever matrix and reagents are running through the system, traces of these liquids will be left after use; proteins from plasma, precipitates from buffers or even particulates from oral fluid. Over time if the following cleaning schedule is not observed these contaminants could cause blockages leading to malfunctions and/or cross contamination.
Tags: Product Notes