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ISOLUTE® Si-TMT

The Gold Standard for Silica Based Metal Scavenging

ISOLUTE si-tmt

ISOLUTE® Si-TMT is the silica bound equivalent of 2,4,6-trimercaptotriazine (TMT). Si-TMT has been shown to efficiently scavenge residual palladium from palladium-catalyzed reactions.

CONSUMABLES

Part No. Description Product type Pack Size Price
538-0050-C 538-0050-C ISOLUTE® Si-TMT 500 mg/6 mL Consumables 30 Log in for price
538-0050-CG 538-0050-CG ISOLUTE® Si-TMT 500 mg/6 mL (Tabless) Consumables 30 Log in for price
9538-0003 9538-0003 ISOLUTE® Si-TMT, 3 g Consumables 1 Log in for price
Si-TMT 9538-0010 ISOLUTE® Si-TMT, 10 g Consumables 1 Log in for price
Si-TMT 9538-0025 ISOLUTE® Si-TMT, 25 g Consumables 1 Log in for price
Si-TMT 9538-0100 ISOLUTE® Si-TMT, 100 g Consumables 1 Log in for price
Si-TMT 9538-1000 ISOLUTE® Si-TMT, 1 kg Consumables 1 Log in for price

Committed to preserving our shared environment – further details available on request.

Can be used in processes in compliance with cGMP standards.

Manufacture of consumables is accredited by the world renowned British Standards Institute.

Flexible supply chains, back up manufacturing and warehousing ensures supply risk reduction

Can be used in processes in compliance with GLP standards.

Products which are scaleable from lab or development to process scale.

Long to indefinite product shelf life, reduced process risk.

Supports pharma guidelines for reducing elemental impurities in APIs.

Further extractable information provided on request.

Raw materials certified free of materials of human or animal origin.

Chemical substances used in our manufacturing process do not require registration.

Able to withstand mechanical stirring and heating under normal reaction conditions.

Download the product note.

 

Background

Palladium-catalyzed reactions are very popular in organic synthesis. Some of the most widely practiced examples include Suzuki-Miyaura cross coupling reactions, Heck reactions, Buchwald aminations, Wacker-type oxidation, hydrogenation, allylation, reductive deallylation and indole formation.

Removal of Metals

Despite the widespread use of these palladium-mediated reactions, removal of residual palladium during workup and product isolation remains a major problem. Reducing the palladium content to the low parts per million (ppm) levels, as is required for active pharmaceutical ingredients, is particularly challenging. Biotage has developed a portfolio of scavenging products designed to remove these transition metal impurities. ISOLUTE® Si-TMT (along with MP-TMT, our polymeric resin variant) are some of the most powerful generic use metal scavengers available.

ISOLUTE® Si-TMT is the silica bound equivalent of 2,4,6-trimercaptotriazine (TMT). Si-TMT has been shown to efficiently remove residual palladium from palladium-catalyzed reactions. The functional group in Si-TMT is attached to a bioanalytical grade silica platform, thus the use of this material does not introduce impurities to the reaction system. There are numerous advantages of functionalized Isolute Silica.

Solvent Independent

Like MP-TMT, Si-TMT neither shrinks nor swells in solvent, which makes it ideal for limited volume development reactors (e.g. microwave vials, 96 well plates and SPE columns).

Fast Kinetics

The functional groups are on the surface and in pores of the silica, (similar to highly cross-linked macroporous polystyrene, MP-TMT) so the rate of reaction is not controlled by diffusion as with traditional 1% cross linked PS-gels.

Simplified Workflow

Si-TMT can be added to a reaction in “batch mode” and stirred in traditional ways, or as a fixed bed in a cartridge. Si-TMT is stable at room temperature and under atmospheric conditions.

Thermally and Mechanically Stable

Most silica based products, can withstand temperatures over 200 °C for short periods of time. They are also stable to mechanical agitation and can be used in conjunction with both magnetic and mechanical stirring.

Application

A Suzuki coupling was performed and scavenging experiments were performed on the mother liquids in both batch and flow mode. The results show that Si-TMT is more efficient in scavenging palladium residues than other silica based metal scavengers.

 

Scavenger

Batch Studies (5 equiv.)

Flow (Cartridge) Scavenging

500 mg/3 mL

100 mg/3 mL

Si-Thiol (Competitor S)

82%

91%

45%

Si-TMT (Biotage)

>99%

>99%

95%