Part No: Issued year: 2017File size: 0.27mbFile type: pdf
This poster describes a simple solid phase extraction method using EVOLUTE® EXPRESS ABN columns for the extraction of the marine toxins okadaic acid (OA), dinophysistoxins (DTX1 and DTX2), ciguatoxin 3C (CTX3C) and tetrodotoxin (TTX).
Part No: AN057Issued year: 2012File size: 0.21mbFile type: pdf
The formation of diarylethers by reacting an arylhalide and phenol is usually a reaction demanding long reaction times, high temperatures and strong bases, in order to obtain acceptable yield. The substitution patent of the electrophile and the nucleophile affects the reaction times mostly. A sterically hindered electrophile and a strongly deactivated nucleophile as outlined in the (Scheme 1) below, gives a very low yield (13 %) at conventional reflux for 2 weeks.1,2 Remainder was
recovered starting material. We have previously reported the dramatically shortened reaction time to 1 hour along with improved yield running the reaction outlined in the Scheme by heating by microwaves.
Part No: BIOMARK97.3Issued year: 2019File size: 0.24mbFile type: pdf
This letter is to inform you that effective April 1st, 2019 Biotage
will phase out the following products:
1. Biotage ZIP®, all column sizes as reported in Table 1
2. Biotage ZIP® Sphere, all column sizes as reported in Table 2
Part No: P131Issued year: 2015File size: 0.47mbFile type: pdf
DMSO and DMF are suitable injection solvents for reversed-phase flash purification. DMSO shows it can be loaded in larger volumes (up to 0.05 mL/g of C18 media or 3.5% of a column volume) without affecting chromatographic separations or carrying compounds with it.
Part No: AN101-HORIssued year: 2016File size: 1.07mbFile type: pdf
This application note highlights a SPE disk which was specifically designed to increase the recoveries of traditionally difficult polar compounds as well as help to increase the diversity of the traditional 525.2 list to include those compounds which are of concern in today’s society.
Part No: P171Issued year: 2017File size: 0.69mbFile type: pdf
This poster demonstrates protocols for the determination of a range of drugs of abuse following collection with the NeoSal™ oral fluid device and GC/MS analysis. The drug suites includes amphetamines and synthetic cathinones, barbiturates, benzodiazepines, cocaine, opiates, cannabinoids and synthetic cannabinoids.
SOFT 2017, Boca Raton
Part No: P174Issued year: 2017File size: 1.44mbFile type: pdf
This poster discusses the potential for a single extraction protocol
for various drugs of abuse classes in whole blood prior to UPLC-MS/MS analysis.
SOFT 2017, Boca Raton
also presented at SFTA, Marseille, France, 2018
Part No: P157Issued year: 2017File size: 0.8mbFile type: pdf
This poster demonstrates that a large urine panel, comprised of 43 DOAs, from multiple drug classes, can be simultaneously screened by mixed-mode cation exchange SPE (using EVOLUTE EXPRESS CX 96 well plates) despite their disparate intermolecular traits, by thoughtfully selecting appropriate organic wash and elution conditions that simultaneously enable sample isolation and detection along with minimizing sample matrix effects.
The extraction method is automated using the Biotage® Extrahera™ Automated sample Preparation Platform.
MSACL 2017, Palm Springs
SOFT 2017, Boca Raton
Part No: DLV_TN.0111Issued year: 2011File size: 0.08mbFile type: pdf
One of the most common flash purification challenges is
dealing with hard-to-dissolve crude samples. Because polar
solvents cause poor chromatographic results when used as
injection solvents in normal-phase flash chromatography, other
sample load options are needed.
Part No: prodes57Issued year: 2019File size: 0.32mbFile type: pdf
The DryDisk® 50 mL Barrel (PN 40-2485) is a disposable sample preparation
device that provides a fast and simple approach for removing
residual water from non-polar solvents. The DryDisk membrane replaces
the conventional sodium sulfate (Na2SO4) drying technique.
Part No: PPS515Issued year: 2019File size: 0.23mbFile type: pdf
The DryDisk membrane drying system provides advantages for removing water from nonpolar solvents, important in protecting the chromatograph in the analysis step, especially critical in protecting GC and GC/MS.
Part No: UI405Issued year: 2015File size: 0.46mbFile type: pdf
Removing water with a membrane rather than the older technique of passing the solvent through a column of sodium sulfate (Na2SO4) brings several advantages. The most important analytically is that the membrane will not adsorb analytes or contaminate the extract with matrix or other potential interferences.
Part No: PPS539Issued year: 2019File size: 0.25mbFile type: pdf
Why spend hours using traditional evaporation techniques when the automated evaporation capability of the DryVap System can take your compound to
dryness in minutes? Through the precise application of vacuum, heat and nitrogen sparge, the DryVap System gently and predictably evaporates all residual solvent from your compound allowing you to quickly move on to the next step.
Part No: P149Issued year: 2016File size: 0.12mbFile type: pdf
With the de-criminalization of recreational cannabis, containing the hallucinogen THC, and other cannabinoids with purported medicinal value, e.g. CBD (Figure 1), in several states a need for higher purity “products” has become a necessity. Current technology uses extraction with supercritical fluids or other non-supercritical solvents to remove the products of interest from other endogenous species such as lipids, terpenes, and chlorophylls as well as pesticides.
These techniques help clean up raw extracts and isolate cannabinoids with higher-purity but not to the levels desired by many producers so there is a developing need for a secondary purification step.
Part No: PPS376Issued year: 2015File size: 1.6mbFile type: pdf
User Case: Kissei Pharmaceutical Co., Ltd. One of Japan’s innovative pharmaceutical companies uses Isolera™ flash
purification systems and Biotage® Initiator+ microwave synthesizers in the
development of new prescription drugs. Modern lab instruments contribute to
efficient use of time and resources at Kissei Pharmaceuticals.
Part No: P143Issued year: 2016File size: 0.27mbFile type: pdf
Buprenorphine and Norbuprenorphine are typically problematic for analysis due to analyte stability issues during sample preparation.
This poster will demonstrate two fast and robust methods for the extraction of buprenorphine and norbuprenorphine in urine (using EVOLUTE EXPRESS CX), oral fluid (using EVOLUTE EXPRESS CX) and whole blood (using ISOLUTE SLE+).