Part No: P020Issued year: 2008File size: 0.16mbFile type: pdf
The trend pharma industry is clearly to speed up the process from lead identification to selection of candidate drug. One of the major limitations is the availability of larger amounts typically hundreds of grams, of the potentially active substance to be further investigated
Part No: P153.v.1Issued year: 2017File size: 1.12mbFile type: pdf
This poster describes a simple but effective method for screening a range of pesticides and drugs of abuse from liver samples. Liver tissue is homogenized using the Biotage® Lysera, and the subsequent extract is cleaned up using ISOLUTE SLE+ supported liquid extraction columns.
Part No: P012Issued year: 2006File size: 0.22mbFile type: pdf
The use of palladium-catalysts in the synthesis of fine chemicals, pharmaceutical intermediates and active pharmaceutical ingredients (APIs) has become quite common in the last few decades. The number of palladiumcatalyzed reactions (both achiral and chiral) available to chemists has provided access to more complex structures in fewer steps and with less waste. An unfortunate side effect of using palladium is the potential for palladiumcontaining impurities to remain in the desired compound after isolation. This is an especially significant problem for the pharmaceutical industry since there is a low limit for heavy metal impurities allowed in the drug substance.
Part No: AN072.v2Issued year: 2013File size: 0.39mbFile type: pdf
Here we present the separation capabilities of a new type of designed adsorbent, RENSA® Boronate. This new resin has affinity for diols and α-hydroxycarboxylic acids and is able to extract those target compounds with high efficiency and selectivity.
Part No: Issued year: 2010File size: 0.26mbFile type: pdf
• Solid-Phase Peptide Synthesis (SPPS) is still often
faced with difficulties in the assembly of long and
‘difficult’ sequences, e.g. due to aggregation and
steric hindrance giving rise to incomplete reactions.
These problems have only partly been solved by
new coupling reagents and solid supports.
• Precise microwave heating has emerged as one
new parameter for SPPS, in addition to coupling
reagents, resins, solvents etc.
Part No: Issued year: 2017File size: 0.31mbFile type: pdf
This poster includes a simple Load-Wash-Elute solid phase extraction method using EVOLUTE EXPRESS WCX, for extraction of aminoglycoside antibiotics from a range of meat, milk and egg samples.
The sample preparation method is automated using Biotage Extrahera, with fast, sensitive analysis utilizing HILIC-MS/MS with MRM Spectrum Mode for ID confirmation (Shimadzu LCMS-8060).
Part No: AN091Issued year: 2014File size: 0.63mbFile type: pdf
Three protected carbohydrate derivatives, 1,2:5,6-Di-O-Isopropylidene-
α-D-glucofuranose, Methyl 4,6-O-Benzylidene-α-D-glucopyranose, and
1,2-O-Isopropylidene-α-D-glucofuranose were successfully separated and
detected, using a Biotage® SNAP KP-Sil cartridge on a Biotage Isolera™ system
with the Biotage® Evaporative Light-Scattering Detector (ELSD) attached.
Part No: AN089Issued year: 2014File size: 0.68mbFile type: pdf
Three sterols, (+)-dihydrocholesterol, β-estradiol-3-benzoate, and
β-estradiol were successfully separated, detected, and isolated using a
Biotage® SNAP KP-Sil cartridge attached to a Biotage Isolera™ One system connected to Biotage® Evaporative Light-Scattering Detector (ELSD).
Part No: TechTipIssued year: 2011File size: 0.06mbFile type: pdf
There are many things that can cause your Speed Vap III to have a problem with the vacuum. Such as the following examples:
1. The compressed air has to flow through the Speed Vap, if there is no exhaust, there is no vacuum. (The exhaust contains solvent vapors and should be properly vented)
2. There may not be sufficient compressed air being delivered to the Speed Vap. (2 CFM is required)
3. If the unit is connected to a Solvent Trap, the rubber stopper that goes into the collection flask may not be making a good seal.
4. The seal on Speed Vap III lid compresses over time and it will need to be replaced to maintain a good seal.
Part No: Issued year: 2007File size: 3.19mbFile type: pdf
Biotage bietet ein umfassendes Jahresservice-Konzept, inhaltlich aller Ersatzteile, Arbeit vor Ort und empfohlener vorbeugender Wartung. Holen Sie sich den Prioritätsstatus für alle Service-Anrufe durch spezialisierte Außendiensttechniker von Biotage und mit
Original-Biotage-Ersatzteilen (wesentlich zur Aufrechterhaltung der optimalsten Geräteleistung).
Part No: Issued year: 2007File size: 0.05mbFile type: pdf
PS-TsNHNH2 and ISOLUTE® Si-TsNHNH2 are solid supported equivalents of p-toluenesulfonyl hydrazide. These reagents are both excellent scavengers for aldehydes and ketones and are generally used in threefold excess with respect to the limiting carbonyl species. A catalytic amount of acetic acid (5-10%) may be required for ketones, hindered substrates or for scavenging in certain solvents (e.g. DMF).
Part No: P022Issued year: 2008File size: 0.09mbFile type: pdf
Microwave-assisted esterification of protected amino acid derivatives was performed using alkyl halides and polystyrene supported TBD1,2 (Fig. 1) as base. The preferred solvents were THF or acetonitrile. The products were obtained in good yields and high purity. Short reaction time, 10 minutes, and easy work-up, filtration and evaporation, constituted a convenient procedure. Benzyl, allyl, phenacyl, and alkyl esters, all important and commonly used derivatives in peptide synthesis, were synthesised.
Part No: AN092-HORIssued year: 2014File size: 1.59mbFile type: pdf
The United States Food & Drug Administration (FDA) regulates the approval of color additives for their safe use in foods, cosmetics, pharmaceuticals/drugs, and medical devices. The Federal Food, Drug, and Cosmetic Act (FD&C Act) contains provisions for what color additives are required to be certified. These provisions are monitored by the FDA, and through the Code of Federal Regulations (CFR), the FDA releases information on new color additives and new uses for certified color additives.