Part No: Issued year: 2010File size: 1.9mbFile type: pdf
User Report: V-10, Sumitomo Dainippon Pharma. Sumitomo Dainippon Pharma is recognized worldwide for its highly creative drug discovery program for treating neuropsychiatric disorders, and in specialized areas with high unmet medical needs. Its Genomic Science Laboratories installed the V-10 evaporation system in 2008, which has been used extensively for drying in-house compounds. We asked two researchers at that facility, Mr. Masahiko Ikeda and Mr. Fumitaka Nishino, about their use of the V-10 in their daily work.
Part No: Issued year: 2005File size: 0.57mbFile type: pdf
Use of the unique opportunities of an academic environment for the synthesis of high-quality libraries of diverse chemical structures to discover small molecules with
architecturally novel scaffolds and a wide range of physicochemical properties and to develop innovative new methodologies for Diversity-Oriented Organic Synthesis
Part No: PPS537.V.1Issued year: 2018File size: 0.68mbFile type: pdf
One of the recent introductions is a system to extract a full range of acid/base neutral compounds from various types of water samples using a One-Pass system. In this case, rather than extract water at pH 2, adjust the pH of the water to 12 and re-extract, the water is passed once through a multi-media SPE disk and then a carbon cartridge before being delivered to waste. The elegance of this approach is the elimination of the basification step, which requires additional labor adjusting the pH and time passing the sample through the disk a second time after the first elution of acids and neutrals. The additional benefit of omitting the basification step eliminates the formation of insoluble metal hydroxides that can restrict the flow of sample through the disk or add significant time if a liquid-liquid extraction is used.
Part No: F0211609_01Issued year: 2011File size: 0.52mbFile type: pdf
Dioxins are persistent organic pollutants (POPs) that are of concern around the world. They need to be efficiently extracted and then are usually measured with HRGC/HRMS using methods such as US EPA 1613 or ISO 18073:2004 for guidance. The SPE-DEX 4790 using solid phase extraction disks is a well-established technology that can be used for this application.
Part No: TN115Issued year: 2006File size: 0.08mbFile type: pdf
This Chemistry Data Sheet describes the use of ISOLUTE® HM-N as a support material for pre-absorption of a
reaction mixture prior to flash chromatography. This approach is used as a solution to loading reaction
mixtures that are only soluble in polar solvents onto an ISOLUTE Flash SI II or Flash NH2 column.
Part No: TN118Issued year: 2006File size: 0.07mbFile type: pdf
ISOLUTE HM-N is a modified form of diatomaceous earth that can efficiently absorb aqueous samples. ISOLUTE HM_N is chemically inert and stable in the pH range 1-13. These characteristics make it a versabile material that plays an important role in many sample preparation applications.
Part No: Issued year: 2006File size: 0.83mbFile type: pdf
• Novo Nordisk A/S & radiochemistry at Novo Nordisk A/S
• Introduction to radiochemistry in general
• Radiochemistry & microwaves
• Selected case stories from the labs at Novo Nordisk A/S
• Applications of radiolabelled compounds
• Summary and acknowledgements
Part No: TechTipIssued year: 2011File size: 0.09mbFile type: pdf
This month’s topic of discussion will be the operation of the valves within the SPE-DEX® 1000/3000 extractors. There are several internal valves in the extractors, the solvent to waste valve, the sample collect valve and the water to waste valve.
Part No: P016Issued year: 2007File size: 0.16mbFile type: pdf
In order to obtain a fast synthesis of an N-unprotected tripeptide, microwave (mw) assisted deprotection, coupling and partial deprotection were applied starting with a purified protected dipeptide [Fig. 1]. The three consecutive mw assisted steps were performed without any intermediate purifications and were accomplished within some 30 minutes. The resulting crude mixture containing the Boc deprotected tripeptide ester was shown to be quite complex [Fig. 2]. The crude product was subjected to automated reversed phase flash chromatography, followed by automated fraction pooling and “thin film evaporation”. The total time for the entire procedure was 1 h 20 min. The purity of the product was > 99%.
Part No: P197Issued year: 2019File size: 1.01mbFile type: pdf
Perfluorinated compounds (PFCs) are a group of compounds that have been used in a wide array of industrial and household applications, including fabric protectors, non-stick coatings for cookware, coatings for food packaging and in some fire-fighting foams.
Their persistence in the environment allows them to accumulate in water sources, particularly those used for consumption.
This work will demonstrate the use of a cartridge-based extraction
system to extract and quantify up to 24 PFC compounds in drinking
water to highlight the challenges associated with this application.