Biotage has developed a range of tools to improve the peptide synthesis workflow, from synthesis of crude peptides through to the final purified product. These solutions make your workflow more efficient and improve the quality of peptides you synthesize. Our workflow solutions are used in pharma, biotech, CRO and academic laboratories throughout the world.
Herein we identified an optimized protocol for removing an Acm protecting group using the Biotage® Initiator+ Alstra™ and applied the protocol for a fully automated synthesis with on-resin disulfide bond formation, simplified with the Branches™ software feature. The results presented herein provide a route amenable to the synthesis of other disulfide rich peptides, greatly reducing the effort put toward synthesizing these complex molecules.