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ISOLUTE SLE liver tissue

Effective Extraction of Illicit Drugs from Liver Tissue

14 September 2016

This application note from the Biotage UK Applications Laboratory demonstrates the use of ISOLUTE® SLE+ as an effective clean-up for the complex liver matrix, and extends the range of toxic analytes that can be extracted into various pesticide classes.


A protocol was developed which allows the simultaneous extraction of various drugs of abuse classes, including amphetamines, barbiturates, benzodiazepines, cocaine, ketamine, and THC. In addition to these drug panels, simultaneous extraction of carbamate, organochlorine, organophosphate, pyrethroid, and triazine pesticide classes is demonstrated.

ISOLUTE SLE+ Supported Liquid Extraction plates and columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation, and significantly reduced sample preparation.

The full procedure is described in the application note, available for download below.