As the popularity of post-synthetic peptide chemistry continues to go, additional purification strategies will be required. Standard reversed phase techniques may be ineffecient due to the extreme hydrophobicity imbued by the presence of sidechain protecting groups. Herein, we demonstrate that normal phase chromatography, specifically the use of a methanol:DCM solvent system and a step gradient, can indeed facilitate rapid purification of fully protected peptides.
Sample Preparation Techniques for Synthetic Benzodiazepines
Good Laboratory Practices Software Upgrade for Biotage® Extrahera™
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