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Extraction of Opiates from Oral Fluid Using ISOLUTE® SLE+

12 January 2017

This application note describes the extraction of opiate compounds from oral fluid matrix collected using the NeoSal™ devices, prior to GC/MS analysis.


This application note describes an effective and efficient ISOLUTE SLE+ protocol optimized for 1 mL sample volumes. The simple sample preparation procedure delivers clean extracts and analyte recoveries greater than 80% with RSDs lower than 10% for all analytes.

ISOLUTE® SLE+ supported liquid extraction plates and columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation, and significantly reduced sample preparation.


  • Dihydrocodeine
  • Hydrocodone
  • Codeine
  • Oxycodone
  • Morphine-D3
  • Morphine
  • Hydromorphone
  • 6-monoacetylmorphine-D3 (6-MAM-D3)
  • 6-MAM
  • Oxymorphone

Download the Application Note below »

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ISOLUTE® SLE+ Supported Liquid Extraction