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Extraction of Synthetic Cannabinoids (SPICE) from Oral Fluid

19 December 2016

This Application Note from Biotage Labs in Cardiff, Wales, describes the extraction of a range of synthetic cannabinoids, also known as SPICE, and metabolites from oral fluid matrix collected using the NeoSal™ devices, prior to GC/MS analysis. 


This effective and efficient ISOLUTE SLE+ protocol is optimized for 1 mL sample volumes. The simple sample preparation procedure delivers clean extracts and analyte recoveries greater than 82% with RSDs lower than 10% for all analytes.

ISOLUTE® SLE+ supported liquid extraction plates and columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation, and significantly reduced sample preparation.


  • UR-144
  • RCS-4
  • JWH-073
  • JWH-018
  • 5-hydroxypentyl-JWH-250
  • 3-hydroxybutyl-JWH-073
  • AM-2201
  • 4-hydroxypentyl-JWH-018
  • 5-hydroxypentyl-JWH-018
  • JWH-200

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ISOLUTE® SLE+ Supported Liquid Extraction