There is nothing more important to purification success with chromatography than compound or sample solubility. Concentrating on just the most popular solvent system of hexane and ethyl acetate may send you down the wrong purification path. Well, in this case it can be easy with just a little chemistry knowledge. If you need to purify a synthetic reaction mix, then you already know your product’s structure as well as those of your starting materials. So, the main question is – in which solvent did you perform the synthesis? The answer to this question can guide your flash purification decision.
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