To facilitate the high throughput population screening of phthalate metabolites, sample preparation methods need to be simple, sensitive and robust to mitigate matrix suppression and instrument down time common to many dilute and shoot approaches to mass spectrometry. Thus, a solid phase extraction procedure was developed for these analytes. This application note details the optimization strategy for nine phthalate metabolites. Proof-of-concept for this sample preparation method was determined on a set of real patient samples (n=5). The results were in general agreement with previously reported concentration ranges for these compounds. It is anticipated that this method will have significant impact in environmental biomonitoring strategies for these analytes.
Update on Biotage’s COVID-19 Response Plan
Smarter Sample Preparation for Environmental Challenges
How does Biotage Act in the Corona Virus Situation?
Sample Preparation Techniques for Synthetic Benzodiazepines
Good Laboratory Practices Software Upgrade for Biotage® Extrahera™