By neutralizing the acidic and protic silica surface with a bonded organic amine, basic compounds such as N-heterocycles, 2°, and 3° amines can be simply and efficiently purified with TLC-based elution data. The results from this research show that the chromatographic purification of organic amine compounds can be improved simply by using an amine-functionalized silica and typical normal-phase solvents such as hexane and ethyl acetate.
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