Perfluorinated chemicals (PFCs), also known as PFAAs, can be found in commercial and industrial uses such as firefighting foams, package material coatings, nonstick cookware, waterproofing and stain proof fabrics. PFCs are all manmade and have unique properties such as repelling water, oil and heat. They are very difficult to break down and persist in the environment.
Tags: Application Notes, Drinking water, English, Environmental, LC-MS/MS, PFAA, PFAAs, Polyfluorinated acids, SmartPrep, US EPA Method 537

The compound 4-methylimidazole (4-MEI) is formed as a byproduct in some foods and beverages. Caramel coloring Type III and Type IV in beverages is one of the ingredients which may contain 4-MEI. Products that potentially contain 4-MEI include certain colas, beers, soy sauces, breads, coffee, ammoniated livestock feed and other products.
Tags: 4-Methylimidazole (4-MEI), Application Notes, Food, Food, Food Additives, Food Colours, LC-MS/MS, SmartPrep

China has set ambitious goals for cleanup and monitoring of drinking water. Methods that are rugged and sensitive are required to support this effort. Chinese Environmental Agency method SL 392-2007 has been developed for this purpose and specifies a C18 cartridge for extraction and GC/MS for the detection step.
Tags: Application Notes, Chinese Environmental Agency Method, Chinese Method SL-392-2007, Drinking water, English, Environmental, GC-MS, SL-392-2007, SVOC, Semi-Volatile Organics, SmartPrep

Worldwide, there is great concern for the presence of semi-volatile organic compounds in surface water, groundwater, and drinking water, such as Aldrin, extremely toxic to fish and a persistent organic pollutant. China has increased concern about drinking water as sources of surface and groundwater have become polluted with microbiological, metal and organic contamination
Tags: Application Notes, Chinese Environmental Agency Method, Chinese Method SL-392-2007, Drinking water, English, Environmental, GC-MS, SL-392-2007, SVOC, Semi-Volatile Organics, SmartPrep

The chemical 1,4-dioxane is primarily used as an industrial solvent or solvent stabilizer. Its carcinogenic classification by US EPA in Group B2 and by the state of California in Proposition 65 (safe harbor limit of 30 μg/day) along with its more recent detection in multiple groundwater supplies across the US have led to its placement on the UCMR 3 list to evaluate its occurrence in drinking water supplies. This has increased demand for testing.
Tags: 1,4-dioxane, Application Notes, English, Environmental, Ground water, SmartPrep

The initial use of many chlorinated pesticides, herbicides, and organohalides were to aid humanity. DDT was created to control mosquito populations which significantly limited the number of malaria and typhus cases in World War II; while the use of Atrazine has increased the production of corn and sugar cane farms and helped to supply the world with the food it so drastically needs.
Tags: Application Notes, EPA 508.1 Analytes, English, Environmental, Insecticides, Organochlorine pesticides (OCP), Pesticides, SmartPrep, US EPA Method 508.1, Water

Disinfection by-products (DBP) are an ever-present nuisance in the efforts to purify drinking water, wastewater and municipal waters from various sources. An emerging class of DBP compounds with health effects is nitrosamines1-3 which result from chloramination or chlorination if the water is nitrogen-rich.
Tags: Application Notes, Drinking water, EPA 521 Analytes, English, Environmental, GC/MS/MS, Nitrosamines, Nitrosamines, SmartPrep, US EPA Method 521

With the promulgation of the third iteration of the Unregulated Contaminant Monitoring Program, testing for the presence of 1,4-Dioxane has become a topic of concern. Primarily used as an industrial solvent or solvent stabilizer, the main hindrances to the recovery of 1,4-Dioxane are both its high water solubility and its volatility.
Tags: 1,4-dioxane, 4790, Application Notes, Aqueous, EPA 522 Analytes, English, Environmental

Mycotoxin testing awareness has increased as countries involved in world trade of raw agriculture and processed consumer products rely on a safe global food supply. Several mycotoxins are naturally produced and monitored; however, aflatoxins, produced mainly by the Aspergillus species, are considered to be the most important mycotoxin group in the world’s food supply to monitor.
Tags: Aflatoxin B1, Aflatoxin B2, Aflatoxin G1, Aflatoxin G2, Application Notes, English, Food, Food, Mycotoxin, SmartPrep

Deoxynivalenol is a common mycotoxin found in wheat agriculture crops. Being the most popular agricultural cereal crop, wheat is also a dietary staple for about 35% of the global human population and animals. Safety of wheat food and agriculture products is a concern, with deoxynivalenol present in 90% of food and feed samples.
Tags: Application Notes, Deoxynivalenol (DON), English, Food, HPLC, Mycotoxin, SmartPrep, Wheat

Mycotoxin testing in consumer food products has become increasingly important as global food trade increases, making it necessary to identify mycotoxins efficiently and accurately. Deoxynivalenol, also known as vomitoxin, is a mycotoxin commonly found in wheat feed crops. Because wheat is a highly-used raw agricultural export commodity in many counties for both animal feed and consumer food products, it is an important component in the diets of both humans and animals.
Tags: Application Notes, Deoxynivalenol (DON), English, Food, Food, HPLC, Mycotoxin, SmartPrep

The global demand for fish as a natural source of fresh animal protein, essential fats, minerals, and vitamins continues to rise with the human population. It is estimated that natural fish resources will not be sustainable, creating the need to increase the available supply of fish through aquaculture.
Tags: Application Notes, English, Fish, Fluoroquinolones, Food, SmartPrep

When a sample preparation technique calls for removal of compounds using SPE, it is standard practice to determine what concentrations will produce an acceptable linear range for the assay. Traditional linear regression is often performed manually using pipettes to generate an external standard curve that unknown samples are measured against.
Tags: Application Notes, Clinical, English, Polysorbate 20, SmartPrep

Routine research at the LVR-Hospital Viersen (Clinic for Psychiatry and Psychotherapy of the National Rhineland Association) includes screening of drugs in human urine. Successful treatment of pain disorders rely on sustainable and objective patient data. Routine Urine Drug Testing (UDT) is fast becoming a common method for obtaining regular results that can be used to effectively manage a patient’s pain therapy.
Tags: Application Notes, Drugs of Abuse, English, SmartPrep, Urine

The United States Food & Drug Administration (FDA) regulates the approval of color additives for their safe use in foods, cosmetics, pharmaceuticals/drugs, and medical devices. The Federal Food, Drug, and Cosmetic Act (FD&C Act) contains provisions for what color additives are required to be certified. These provisions are monitored by the FDA, and through the Code of Federal Regulations (CFR), the FDA releases information on new color additives and new uses for certified color additives.
Tags: Application Notes, English, Food, Food, Food Additives, Food Colours, Food contaminant, SmartPrep

The US EPA has implemented an exposure research program aimed at conducting drinking water research on methods as part of the Microbiological and Chemical Exposure Assessment. This research is aimed at evaluating the chemical pollutants and their role and levels in which there is an unacceptable risk to either humans or wildlife, as well as evaluating the methodologies currently being used to determine levels of chemical pollutants
Tags: Acetamide, Application Notes, Chloroacetanilide, Drinking water, EPA 535 Analytes, English, Environmental, SmartPrep, US EPA Method 535

Deoxynivalenol is a common mycotoxin found in agricultural grain crops and final consumer processed products. Most impacted are wheat, barley, and corn. Deoxynivalenol, also known as Vomitoxin, is produced by Fusarium fungi and has a unique dual-stage growth cycle of producing mold during warm daylight and toxin during cool nights. There is no known procedure or processing that will remove deoxynivalenol that is already present in grain.
Tags: Application Notes, Deoxynivalenol (DON), English, Food, Food, Mycotoxin, SmartPrep

Within EPA Method 549.2, the suggested rate to load a sample onto a solid phase cartridge is given as 3 to 6 mL/min. This Application Note outlines the process used to extract diquat and paraquat from water samples using a faster loading rate than given by the EPA in method 549.2
Tags: Application Notes, Column, Diquat, Drinking water, EPA 549.2 Analytes, English, Environmental, HPLC, Paraquat, SmartPrep

This Application Note outlines the process used to extract diquat and paraquat from water samples using the Biotage Horizon SmartPrep Automated Solid Phase Cartridge Extractor, according to EPA method 549.2.
Tags: Application Notes, Column, Diquat, EPA 549.2 Analytes, English, Environmental, HPLC, Paraquat, SmartPrep, Water

The focus of this Application Note is to illustrate some of the advances which have been made when performing EPA method 525.2 when using Solid Phase Extraction (SPE). It will make use of the Biotage(r) Horizon SmartPrep Automated Cartridge Extraction system set up to run in Bottle Rinse Mode with 6 mL SPE cartridges.
Tags: Application Notes, Column, Drinking water, EPA 525.2 Analytes, EPA 525.2 Analytes, English, Environmental, GC-MS, SmartPrep, US EPA Method 525.2

Solid Phase Extraction (SPE) cartridges have been used for many years, and are well established as a proven extraction, clean-up, and fractionation technique for a wide variety of sample matrices. As such, a diverse set of chemistries are available to handle these various samples. For all of this work, cartridges can be used manually, via a manifold-type setup, or with an automated system, which would simply automate the manual steps.
Tags: Application Notes, English, Environmental, SmartPrep, Water

Based on samples to be processed, the final analytical technique to be employed, or the need to develop and optimize an analytical extraction method, there are times when it is desirable to collect multiple elution fractions from a single sample.
Tags: Application Notes, English, Environmental, SmartPrep, Water

Analytical methods which extract aqueous samples require that the initial volume of the sample be determined, as it is necessary to calculate the concentration of the analytes in the sample. Typically, this is done by marking the sample meniscus on the side of the sample bottle before the sample is extracted.
Tags: Application Notes, English, Environmental, SmartPrep, Water

The SmartPrep II Cartridge System is designed for simple automation of manual solid phase extraction (SPE) methods. Just like manual SPE, up to 12 samples per SmartPrep II System can be run in one batch.
Tags: Brochures

Tags: Certificates

Tags: Certificates

The compound 4 Methylimidazole (4-MeI) is made during the production of caramel color commonly found in foods and beverages, especially sodas. The Codex Alimentarius of the World Health Organization sets a limit of 250 mg/kg of 4-MeI. Also, the state of California has added 4-MeI to its Prop 65 list at an exposure level of 29 μg/day. This study looks at 4-MeI levels in sodas and malt sodas which are sold in and outside the state of California. The first section, included in this poster, describes the performance of automated solid phase extraction of 4-MeI using conventional HPLC/MS detection. ASMS 2018, San Diego, CA
Tags: 4-Methylimidazole (4-MEI), Carbonated soft drink (soda), Column, English, Food, Food contaminant, LC-MS/MS, Posters

Solid Phase Extraction (SPE) is an excellent mechanism to extract and concentrate PFCs from drinking water and isolate the compounds of interest from interferences and is a standard part of the method » Automation for the SPE step provides a number of advantages in this analysis including improving reproducibility and reducing the chance of contamination » This work demonstrated compliance with quality control requirements of US EPA method 537 and overall excellent results
Tags: Posters

This poster describes the use of the Biotage® Horizon SmartPrep Automated Cartridge Extraction System for extraction of PFC's from water. APHL 2018
Tags: Column, Drinking water, English, Environmental, Perfluorobutanesulfonic acid (PFBuS), Perfluoroheptanoic acid (PFHpA), Perfluorohexanesulfonic acid (PFHxS), Perfluorononanoic acid (PFNA), Perfluorooctanesulfonic acid (PFOS), Perfluorooctanoic acid (PFOA), Polyfluorinated acids, Posters

Tags: Product Notes, Sole Source/Lockout Specs

To improve upon the original SmartPrep Cartridge Extractor’s design, the SmartPrep Cartridge Extractor II includes a Ceramic Seal in each valve rather than a Rulon® Seal. These Ceramic Seals were specially selected to increase the durability of the valves with tough sample matrices, including those that may be abrasive.
Tags: Product Notes

SmartPrep automated cartridge extractor is the key to working through the method development process. SPE automation only requires the user to setup development parameters in the software and the instrument does the rest. While the SmartPrep takes care of the SPE method development steps, an LC or LC/MS method can be developed.
Tags: Product Notes

Solid Phase Extraction (SPE) is one of the most common sample preparation techniques that can be automated with simplicity. The SmartPrep Extractor Software offers an easy and intuitive interface specifically designed to streamline the manual SPE process for 1, 3, and 6-mL cartridges. No specialized training or expertise is needed to run samples. Any technician level from novice to expert can quickly get started with SPE sample processing.
Tags: Product Notes

Automating Solid Phase Extraction (SPE) can be simple and efficient with the SmartPrep Extractor. Designed for laboratories transitioning from manual to automated SPE, the SmartPrep Extractor focuses on the essential SPE process to run a variety of sample matrices and volumes without dedicated experts.
Tags: Product Notes

Solid phase extraction (SPE) of transformer oils, biofuels, edible, and essential oils can offer challenges of working with difficult matrices, multiple methods, and hazardous solvents. The SmartPrep Oil & Fuel Extractor systems are complete with racks, sample tubes, and accessories packaged to automate the typical manual SPE oil and fuel procedures, removing the challenges of working with oils and fuels, while providing a consistent and simple approach to running multiple methods on the same platform.
Tags: Product Notes

Tags: Product Notes, Sole Source/Lockout Specs

Unique Specifications for the Biotage® Horizon SmartPrep® Automated Cartridge Based Solid Phase Extraction System II
Tags: Sole Source/Lockout Specs