
This product has been phased out on October 1st, 2019.
Please check out here the corresponding column in the Biotage® Sfär family: Biotage® Sfär High Capacity Duo
Biotage SNAP Ultra flash chromatography cartridges deliver the highest purification performance available. Packed with Biotage® HP-Sphere™ spherical silica, these cartridges have the highest loading capacity, lowest backpressure and can withstand high flow rates.
Sizes | 10 g, 25 g, 50 g, 100 g, 340 g |
Tube Material | Inert medical-grade polypropylene |
Frit Material | Inert polyethylene |
Pressure Range | 0-100 psi / 7 bar (75 psi / 5 bar for 340 g) |
Media | Biotage® HP-Sphere - 25 micron spherical silica |
Resolution | Minimum 7000 N/m (plates per meter); typical 10 000 N/m |
Compatibility | Universal Luer connections |
The term “Green Chemistry” has become a major part of the
science community’s lexicon. In this application note we will
look at two areas for flash chromatography:
1. Replacing chlorinated solvents with those considered more
environmentally friendly.
2. Reducing solvent use and waste generation with more
thoughtfully applied chromatography principles.
Tags: Application Notes
Normal-phase flash chromatography1 has been widely adopted as the method of choice for separation of product mixtures and reaction by-products. One of the most significant developments in this
area concerns the practical separation of polar molecules. Reversed-phase purification is a modification of normalphase
chromatography that provides an efficient mechanism for the separation of polar compounds.
Tags: Application Notes,
Brochures,
English,
Manuals & User Guides
Pyrazines are a class of organic molecules often used to provide flavor to foods. They are typically synthesized but some are found in fruits and vegetables, e.g. grapes, bell peppers, peas, asparagus, beetroot, tobacco, and roasted foods. Pyrazine’s heterocyclic chemistry can yield some challenges to their purification due to the various separation kinetics between the compound and silica. Biotage SNAP Ultra.
Tags: Application Notes,
English
Biotage Sfär columns are quality tested to ensure they meet
stringent performance criteria including efficiency and peak
symmetry. Each CE-marked column is built using inert, foodgrade
plastics for lower extractables, cleaner fractions, and
packed to provide excellent resolution.
Tags: Brochures
Biotage has developed tools for every
step of the organic process, with the entire workflow in mind.
This dedicated suite of products vastly expands the
range of options in order to truly accelerate discoveries
of new molecules for future innovations.
Tags: Brochures
Normal-phase flash chromatography1 has been widely adopted as the method of choice for separation of product mixtures and reaction by-products. One of the most significant developments in this
area concerns the practical separation of polar molecules. Reversed-phase purification is a modification of normalphase
chromatography that provides an efficient mechanism for the separation of polar compounds.
Tags: Application Notes,
Brochures,
English,
Manuals & User Guides
Interview with Dr. László Kürti and Nicole Behnke at Rice University in Texas about their recent projects, how they use the Isolera™, and
interesting chemistry .
Tags: Customer Cases
User report: Flash instruments. Chugai Pharmaceutical uses Biotage flash chromatography products for drug discovery research. When deciding to convert from manual open-column procedures to automated systems, they chose successive generations of Biotage products, ranging from the Flash+® packed column to the Biotage® Horizon, SP1, Isolera™ Spektra, and Isolera™ Dalton automated flash chromatography systems.
Tags: Customer Cases
It is important to understand there are design differences between
SNAP and Sfär Samplets, and that SNAP Samplets cannot be used on
Sfär columns and vice versa. See samplet-column compatibility table on the next page.
Tags: Manuals & User Guides,
Product Notes
Biotage®SNAP Ultra cartridges are compatible with CombiFlash® Rf Systems. As a convenience, Biotage SNAP Ultra cartridges with Luer slip connectors are available. Contact your Biotage representative for ordering information.
Tags: Manuals & User Guides
Flash purification involves a simple liquid chromatography technique
» Method development uses TLC as a way of deciding the parameters for the
separation
» Isocratic separations are easiest to develop, but gradient separations are
more powerful
» Software in the Isolera helps with conversion of an isocratic separation to
a gradient
» It is possible with the Spektra software to run step gradients
» Loading options are dependent on the column type
» SNAP offers the most flexibility
» Care must be taken to choose the best loading option to get good
purifications
Tags: Manuals & User Guides
Normal-phase flash chromatography1 has been widely adopted as the method of choice for separation of product mixtures and reaction by-products. One of the most significant developments in this
area concerns the practical separation of polar molecules. Reversed-phase purification is a modification of normalphase
chromatography that provides an efficient mechanism for the separation of polar compounds.
Tags: Application Notes,
Brochures,
English,
Manuals & User Guides
Laboratory chemical
Not for therapeutic or diagnostic use
Tags: English,
Material Safety Data Sheets
In medicinal chemistry, organic synthesis will generate by-products with similar chemistry to the product. Separating these impurities from the product often becomes a challenge that often only prep HPLC can achieve.
In this poster, we discuss how using sample dry loading with a cation exchange scavenger media with flash chromatography
improves product purity by removing many of the impurities.
Tags: Posters
New, higher default flow rates enabled by Isolera ACI systems decreases purification times compared to other systems’ and cartridges’ default flow rate settings without sacrificing separation efficiency. Incorporation of gradient optimization by converting a linear gradient to a step gradient further reduces purification time and solvent use while maintaining separation integrity for a target molecule.
Tags: Posters
SNAP Ultra cartridges increase purification throughput and product purity compared to larger standard silica cartridges.
Tags: Posters
It is important to understand there are design differences between
SNAP and Sfär Samplets, and that SNAP Samplets cannot be used on
Sfär columns and vice versa. See samplet-column compatibility table on the next page.
Tags: Manuals & User Guides,
Product Notes
Biotage® Selekt purification platform working in tandem with improved Biotage® Sfär columns has led to a leap forward in speed of purification and a downward trend in solvent consumption. Our team has crunched the numbers, and we’re more than happy to reveal the results.
Tags: Product Notes
Bei herkömmlichen Aufreinigungsverfahren mittels Chromatographie kommen große Mengen verhältnismäßig giftiger und teurer Lösungsmittel zum Einsatz, die sich negativ auf den ökologischen Fußabdruck von Unternehmen in der Molekularforschung auswirken. Neue Richtlinien für einen verantwortungsvolleren Umgang mit Chemikalien zwingen Unternehmen, die Umweltauswirkungen ihrer Arbeit zu reduzieren. Durch Einblicke in die Arbeitsabläufe dieser Unternehmen und neue Entwicklungen im Bereich Flash-Chromatographiesysteme und -säulen lassen sich Verbrauch und Toxizität der für die Aufreinigung eingesetzten Lösungsmittel und somit auch die Umweltbelastungen dieser Verfahren reduzieren.
Tags: Environmental,
German,
Product Notes,
White Papers
Traditional approaches to compound purification involving chromatography utilize large volumes of relatively toxic and expensive solvents, and significantly contribute to the environmental footprint of organizations involved in molecular research. Current directives for greener chemistry have put pressure on organizations to reduce the
environmental impact of their work.
Tags: Environmental,
Product Notes,
White Papers
Improve compound purity and flash chromatography throughput by up to
3 times while conserving solvents using Biotage® SNAP Ultra cartridges on
Reveleris® Flash Chromatography Systems from Grace.
Tags: Product Notes
To save money on consumables, many chemists choose to reuse
silica flash cartridges. This is true but risks purification results because chromatographic separation performance will change from run to run which reduces purification quality, especially in normal phase systems.
Regardless of the cartridge brand used, repeated use of silica flash cartridges results in loss of compound resolution and therefore fraction purity.
Tags: Product Notes
With running costs and time a concern in most labs, ACI™ now promises to take users to the end point even faster and even more efficiently.
Tags: Product Notes
Precision engineered Biotage SNAP Ultra cartridges deliver double
the purification capacity utilizing small particle spherical silica with
an 40% increase in surface area. This proprietary silica reduces
peak width and provides higher concentration fractions with less
fraction volume.
Tags: English,
Product Notes
Die Flash-Chromatographie ist die bevorzugte
Reinigungsmethode für organische Stoffe, Arzneimittel und
Naturstoffe. In jüngster Zeit hat sie auch die Peptidchemie
erobert, verfügt sie doch über die Fähigkeit, eine Vielzahl
unterschiedlicher Verbindungen effizienter zu trennen, als dies
mit anderen Vorreinigungsverfahren wie z. B. dem Ausfällen
(Protein-Crash) oder der Flüssig-Flüssig-Extraktion möglich ist.
Zur Herstellung reiner Verbindungen können Chemiker je nach
dem gewünschten Reinheitsgrad auf eine Vielzahl unterschiedlicher
Variablen zurückgreifen. In diesem Whitepaper möchten
wir die Faktoren erläutern, die für eine erfolgreiche Aufreinigung
mithilfe der Flash-Chromatographie kontrolliert werden müssen.
Tags: White Papers
Bei herkömmlichen Aufreinigungsverfahren mittels Chromatographie kommen große Mengen verhältnismäßig giftiger und teurer Lösungsmittel zum Einsatz, die sich negativ auf den ökologischen Fußabdruck von Unternehmen in der Molekularforschung auswirken. Neue Richtlinien für einen verantwortungsvolleren Umgang mit Chemikalien zwingen Unternehmen, die Umweltauswirkungen ihrer Arbeit zu reduzieren. Durch Einblicke in die Arbeitsabläufe dieser Unternehmen und neue Entwicklungen im Bereich Flash-Chromatographiesysteme und -säulen lassen sich Verbrauch und Toxizität der für die Aufreinigung eingesetzten Lösungsmittel und somit auch die Umweltbelastungen dieser Verfahren reduzieren.
Tags: Environmental,
German,
Product Notes,
White Papers
Traditional approaches to compound purification involving chromatography utilize large volumes of relatively toxic and expensive solvents, and significantly contribute to the environmental footprint of organizations involved in molecular research. Current directives for greener chemistry have put pressure on organizations to reduce the
environmental impact of their work.
Tags: Environmental,
Product Notes,
White Papers
Dear Valued Customers, We value your continued support and therefore want to notify you of a change in our product line - the discontinuation of the Biotage® SNAP and Biotage® SNAP Ultra p...
09 August 2018Want to improve your flash chromatography skills? Learn all the tricks of the trade in this one-hour webinar with flash guru Bob Bickler. For a dedicated synthetic chemist, the goal ...
20 November 2017Although linear synthesis of protected peptides is generally straightforward, purification of these compounds using traditional reversed phase methods is quite challenging. A poster from ...
25 October 2017Models have shown that the time taken to produce a target molecule can be reduced by up to eighty percent. Today, chemists multitask to be more efficient, but this does not reduce the actual time t...
19 October 2017Developments in instrumentation and consumables around Flash purification can reduce solvent consumption levels of a typical drug discovery workflow by 50% or more. This is achieved ...
31 May 2017"Normal-phase silica has, on average, 50 to 60 Å pores (and a surface area of 500 m²/g). However, for small-molecule reversed-phase chromatography to be useful, the average pore siz...
07 November 2016Senior Technical Specialist Bob Bickler digs into the limiting factors for sample load in flash chromatography on the Flash Purification Blog. "A question I hear a lot from chemists ...
18 March 2016The industry standard platform for flash purification, Isolera™, is given a basic presentation by our German account manager in this short video. Isolera™ ist ein Flash C...
04 March 2016This application note describes a simple and robust way to swap to more environmentally friendly solvents in flash purification. In this application, Biotage® SNAP Ultra 25 g cartridges ar...
02 March 2016The term column volume, typically abbreviated CV, is a value used to help determine separation quality and loading capacity. But how can this concept and its definition be better understood? Bob Bi...
13 November 2015This blog post on the Flash Purification Blog discusses the process of simplified flash purification scale-up. For many chemists performing bench-scale organic synthesis, flash column chro...
16 September 2015ACI™ - Accelerated Chromatographic Isolation is a revolutionary advancement converting regular flash from simple purification to the fastest, greenest, and most economical way to reliably iso...
11 September 2015A new post on the Flash Purification Blog addresses the question "Normal or reversed phase in flash chromatography". There is nothing more important to purification success with chromatogr...
01 September 2015Techincal specialist Bob Bickler goes through a good method to optimize column size for your purification in his latest blog post on The Flash Purification Blog. "In all my years of work...
30 June 2015Biotage® SNAP Ultra flash cartridges allow you to load your samples in seven different ways. No matter what you are purifying - there is always a solution to get the best possible separati...
22 May 2015"The real benefit of this column is that it has a much higher loading, up to 4 times the amount you would get on a normal column". Dr. Greg Saunders explains all the benefits of using a Biotage®...
24 April 2015Japanese chemical detectives have used Isolera™ Dalton mass-driven flash chromatography system and Biotage® SNAP Ultra flash cartridges to identify the origins of traditional medicin...
27 March 2015Biotage, pioneers in flash chromatography, started packing columns with silica for flash purification 30 years ago. Some of the first employees are still with us today. In this video, site director...
11 March 2015Chugai Pharmaceutical in Japan have worked through nearly every piece of flash equipment from Biotage. Here they explain why - and what they expect from the future. Three research ch...
04 February 2015Biotage will attend the 22nd SCT Young Researchers in Paris, France 4-6 February 2015 Read More http://www2.sct-asso.fr/form.php?langue=english&cle_menus=1187970162
16 December 2014Users running flash chromatography systems other than Isolera™ can still benefit from the high performance of Biotage® SNAP Ultra flash cartridges. Biotage®SNAP Ultra cartrid...
04 December 2014Regardless of the cartridge brand used, repeated use of silica flash cartridges results in loss of compound resolution and fraction purity. To save money on consumables, many chemists choo...
20 November 2014Which cartridge should I use? How do different silica gels influence my purification? What is the correlation between the Rf value and column volume? What's the difference between isocratic and ste...
13 October 2014Fragrance compounds, being invisible to UV, can be elusive and difficult to isolate. In this application, a four component mixture of fragrance compounds was purified using Accelerated Chromatograp...
12 September 2014The capabilities of Biotage flash chromatography systems for providing pure compounds from natural products is confirmed in an extensive Korean study of active compounds in the medicinal herb&...
06 August 2014Fatty acids and their esters are found in many biological substrates. Many of these fats are unhealthy (e.g. saturated fats) while others have been found to be beneficial (e.g. unsaturated, polyuns...
29 July 2014Buy your Biotage consumables through our website and shipping is free For a limited time, free shipping is applied to Biotage consumables orders through the Biotage website*. Let Biotage make orde...
27 June 2014Uppsala, Sweden, 27th June, 2014 – Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, announces the launch of ACI&trad...
14 March 2014By Dr. Greg Saunders, EU Marketing Manager for Organic and Peptide Chemistry at Biotage Liquid chromatography (LC) is used for two different purposes – analytical work and purification &ndas...
31 January 2012Introducing the new Biotage® SNAP Ultra high performance flash chromatography cartridges utilizing Biotage® HP-Sphere™ spherical silica. Uppsala, Sweden, January 31, 2012 &nd...
18 October 2011Preparative FLASH chromatography expedites the production of clinical trial compounds. Tobi Williams is an application chemist specializing in pilot and production purification at Biotag...
Isolera™ Prime is a value based system which recommends appropriate cartridges and calculates the best solvent conditions and gradients for your purifications. It has solvent pumps, automated fraction collection as standard and delivers much more than just the basics. Solvent use is minimized and advanced compound detection makes sure that your purified compound is delivered at the end of the run. We belive in providing value, so Isolera Prime systems embrace ACI™, a revolutionary advancement, converting regular flash from simple purification to the fastest, greenest, and most economical way to reliably isolate pure compounds for organic synthesis. ACI offerred as standard on Isolera Prime.
Isolera™ Dalton is the most advanced and innovative flash purification system available, designed by people who understand flash chromatography for the chemists who need it.
"Pure convenience! Just pure convenience! It lets us perform purification and analysis at the same time. It gives us tremendous power to isolate unknown compounds.”
- Hiroki Nishii, Chugai Pharmaceutical’s Kamakura Research Laboratories
The new Biotage® Selekt Flash Purification System is a system you can use with Konfidence.
Biotage® Sfär Silica HC D is the obvious choice when you need to run the best possible separation with the smallest amount of silica and solvent and, at the same time, have the flexibility to load your sample in six different ways.
Biotage Sfär Silica HC D- High Capacity Duo 20 μm provides maximum resolving power and has sample load methods twice (or more) that of other columns. It’s suitable for more complex separations, or when you have high requirements in terms of high resolution, high purity or quantity of the final compound and flexibility in the way you load your sample.
Precision engineered Biotage® SNAP Ultra cartridges deliver double the purification capacity of other flash cartridges. The 25 micron Biotage® HP-Sphere spherical silica has a 40% higher in surface area compared to lower surface area silicas.
The small 25 μm spherical particles minimize band-broadening, whilst supporting faster flow rates to speed purification and improve productivity. Performance like this means a small SNAP Ultra cartridge can replace a more expensive large alternative cartridge.
Through increased productivity, enhanced loading and significantly improved resolution, SNAP Ultra cartridges are Biotage ACI™compliant. Biotage ACI™ – Accelerated Chromatographic Isolation standards set the scene for purification, taking regular flash to the next level. Read more about ACI here »
Isolera™ software and Biotage® SNAP Ultra cartridges work together as a system to produce pure compounds the first time. Luer lock inlet and outlet ports ensure robust connection to the Biotage Isolera or any other flash chromatography system. Wide range of sizes for scalability Biotage SNAP Ultra cartridges are available from 10 g to 340 g sizes providing simple and direct scale-up of samples from low milligrams to multi-grams.
Part No. | Description | Product type | Pack Size | Price | ||
DLV-031 | 27mm FLASHPACK plunger o-ring (DLV030) | Consumables | 2 | Log in for price | ||
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DLV-035 | Dry load vessel cartridges with frits 30 g, 20/cs | Consumables | 20 | Log in for price | |
DLV-071 | 37mm FLASHPACK plunger o-ring (DLV070) | Consumables | 2 | Log in for price | ||
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DLV-075 | Dry load vessel cartridges with frits 70 g, 20/cs | Consumables | 20 | Log in for price | |
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SAS-0442-0010 | Biotage® SNAP Ultra Samplet 1 g, 20/cs | Consumables | 20 | Log in for price | |
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SAS-0442-0025 | Biotage® SNAP Ultra Samplet 3 g, 20/cs | Consumables | 20 | Log in for price | |
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SAS-0442-0100 | Biotage® SNAP Ultra Samplet 10 g, 20/cs | Consumables | 20 | Log in for price | |
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SAS-0442-0340 | Biotage® SNAP Ultra Samplet 34 g, 6/cs | Consumables | 6 | Log in for price |
Part No. | Description | Product type | Pack Size | Price | ||
413127 | DLV-030 and -070 holder four use with SNAP 10g through 100g cartridges | Accessories | 1 | Log in for price | ||
413128 | DLV-030 and -070 holder for use with SNAP 340g cartridges | Accessories | 1 | Log in for price | ||
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DLV-030 | Dry load vessel kit, 30g | Accessories | 1 | Log in for price | |
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DLV-070 | Dry load vessel kit, 70g | Accessories | 1 | Log in for price |